CD28 antibody [CD28.2], IgG1, Unconjugated, Mouse, Monoclonal
Artikelnummer:
GTX13463
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| Artikelname: | CD28 antibody [CD28.2], IgG1, Unconjugated, Mouse, Monoclonal |
| Artikelnummer: | GTX13463 |
| Hersteller Artikelnummer: | GTX13463 |
| Alternativnummer: | GTX13463-100 |
| Hersteller: | GeneTex |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FC, ICC, IHC-Fr, IP |
| Spezies Reaktivität: | Human, Mouse, Primate |
| Immunogen: | human CD28 transfected murine T cell hybridoma. |
| Konjugation: | Unconjugated |
| Alternative Synonym: | CD28 molecule , Tp44 |
| The CD28.2 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between the B7 ligands and CD28 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response. Other members of the CD28 family of receptors include CTLA-4 (CD152), PD-1 (CD279), ICOS and BTLA. |
| Klonalität: | Monoclonal |
| Konzentration: | 0.5 mg/ml (Please refer to the vial label for the specific concentration.) |
| Klon-Bezeichnung: | [CD28.2] |
| Isotyp: | IgG1 |
| Sensitivitaet: | Recognizes the CD28 (44 kDa) human cell surface disulfide-linked, homodimeric glycoprotein. The antibody reacts with human CD28-transfected murine T-cell hybridoma, PHA-activated blasts and IL-6 dependent plasmacytoma lines. It cross reacts with rhesus mo |
| NCBI: | 940 |
| UniProt: | P10747 |
| Puffer: | 10mM NaH2PO4, 150mM NaCl, 0.09% Sodium azide. |
| Formulierung: | Liquid |
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