Chemical Name: (2R,3S)-N-[(2S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N,3-dihydroxy-2-(2-methylpropyl)butanediamide
MMP inhibitor
Molekulargewicht:
331.41
Reinheit:
98% by HPLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[154039-60-8]
Formel:
C15H29N3O5
Anwendungsbeschreibung:
Marimastat is an orally bioavailable inhibitor of matrix metalloproteinases (IC50s: MMP-1 = 5 nM, MMP-2 = 6 nM, MMP-3 = 200 nM, MMP-7 = 20 nM, MMP-8 = 2 nM, MMP-9 = 3 nm, MMP-14 = 1.8 nM).1 It has been used to alter the extracellular matrix of the tumor microenvironment in various liposomal3,4 and nano-platforms5-7 along with other therapeutic agents.
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