Chemical Name: 5-[(4S)-4-Hydroxy-4-methyl-1,2-oxazolidine-2-carbonyl]-3-methyl-6-[[5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]-1-propan-2-ylthieno[2,3-d]pyrimidine-2,4-dione
MCT1 inhibitor
Molekulargewicht:
515.51
Reinheit:
98% by HPLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[1448671-31-5]
Formel:
C21H24F3N5O5S
Anwendungsbeschreibung:
AZD3965 is a potent inhibitor (Kis: 1.6 - 3.2 nM) of monocarboxylate transporter 1 (MCT1) with approximately 6-fold selectivity over MCT2.1 Active in multiple cancer models as monotherapy or in combination with other chemotherapeutics.2 AZD3965 improved CAR-T cell therapy against B-cell malignancies.3 It inhibited lipid biosynthesis and increased tumor infiltration of dendritic and natural killer cells.4 Combination therapy with immune checkpoint blockade suppressed lactate-mediated immunosuppression in the tumor microenvironment.5
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