MLLT10, AF10, Protein AF-10, ALL1-fused gene from chromosome 10 protein
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 Lys-79 dimethylation (H3K79me2) and gene activation (PubMed:26439302).
