SAM68 (16X9) Rabbit Monoclonal Antibody, Unconjugated
Artikelnummer:
EKL-AMRE17587
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| Artikelname: | SAM68 (16X9) Rabbit Monoclonal Antibody, Unconjugated |
| Artikelnummer: | EKL-AMRE17587 |
| Hersteller Artikelnummer: | AMRe17587 |
| Alternativnummer: | EKL-AMRE17587-50UL, EKL-AMRE17587-100UL, EKL-AMRE17587-200UL |
| Hersteller: | EnkiLife |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ICC, IHC, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Konjugation: | Unconjugated |
| Alternative Synonym: | Khdrbs1, p62, p68, Sam68, |
| Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. According to some authors, is not involved in the nucleocytoplasmic export of unspliced (CTE)-containing RNA species according to (PubMed:22253824). RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds to RNA containing 5-[AU]UAA- 3 as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). Can regulate CD44 alternative splicing in a Ras pathway- dependent manner (By similarity). In cooperation with HNRNPA1 modulates alternative splicing of BCL2L1 by promoting splicing toward isoform Bcl-X(S), and of SMN1 (PubMed:17371836, PubMed:20186123). Can regulate alternative splicing of NRXN1 and NRXN3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. In a neuronal activity-dependent manner cooperates synergistically with KHDRBS2/SLIM-1 in regulation of NRXN1 exon skipping at AS4. The cooperation with KHDRBS2/SLIM-1 is antagonistic for regulation of NXRN3 alternative splicing at AS4 (By similarity). |
| Klonalität: | Monoclonal |
| Molekulargewicht: | 48kDa |
| NCBI: | 10657 |
| UniProt: | Q07666 |
| Puffer: | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% New type preservative N and 50% glycerol. Store at +4C short term. Store at -20C long term. Avoid freeze / thaw cycle. |
| Reinheit: | Affinity purification |
| Formulierung: | Liquid |
| Target-Kategorie: | KHDRBS1 |
| Application Verdünnung: | WB 1:5000-1:50000,IHC 1:100-1:200,ICC/IF 1:100-1:200 |
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