The antiserum was produced against synthesized peptide derived from human TR-beta1 around the phosphorylation site of Ser142. AA range:116-165
Alternative Synonym:
THRB, ERBA2, NR1A2, THR1, Thyroid hormone receptor beta, Nuclear receptor subfamily 1 group A member 2, c-erbA-2, c-erbA-beta
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008],
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Western blot analysis of lysates from 293 cells treated with PMA 125ng/ml 30, using TR-beta1 (Phospho-Ser142) Antibody. The lane on the right is blocked with the phospho peptide.
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