PptT-IN-4 (Compound 3a) is a small molecule inhibitor of the PptT enzyme with an IC50 of 0.71 µM, demonstrating antimycobacterial activity against M. tuberculosis H37Rv (MIC = 42 µM). It also shows moderate inhibition of hERG, hCav1.2, and hNav1.5 ion channels. This compound is a useful research tool for studying mycobacterial pathogenesis and for in vitro pharmacology and safety assessment.
