Compound 22 is a triazole-modified geldanamycin analog that binds Hsp90 with a Kd of 3.86 µM. It demonstrates cytotoxic activity with an IC50 of 3.38 µM in HDF cells, inducing apoptosis. This small molecule is a useful research tool for studying Hsp90 inhibition in cancer biology and apoptosis mechanisms in vitro.
Molekulargewicht:
742.86
Formel:
C40H50N6O8
Target-Kategorie:
Apoptosis
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