HBV, HBX, hepatitis B, Hepatitis B virus, Hepatitis B virus X protein (HBx), HepG2, Inhibitor, inhibit, IR415, IR-415, IR415-HBx interaction, IR 415, cell, replication, VSR, virus
IR415 is a potent small molecule inhibitor of Hepatitis B virus (HBx) with a 2 nM binding affinity. It blocks HBx-mediated suppression of RNAi by restoring dicer endoribonuclease activity, thereby inhibiting HBV replication. This mechanism supports its utility in both in vitro and in vivo virology and antiviral research.
