cystitis, E. coli, Bacterial, antimicrobial, Antibacterial, Antibiotic, Nitrofurantoin, Macrodantin, inhibit, kidney, infection, Inhibitor, Furadantine, Furadonine, urinary tract, UTI
Nitrofurantoin is a broad-spectrum urinary antibiotic that inhibits bacterial nucleic acid and cell wall synthesis. It is activated by bacterial flavoproteins to form reactive intermediates which inactivate ribosomal proteins. This mechanism supports its use in research involving bacterial infection models, both in vitro and in vivo, for studying antimicrobial prophylaxis and suppression.
