AMPKalpha, AMPK, AMP-activated protein kinase, Inhibitor, hepatic LO2, Nur77, LKB1, inhibit, TMPA, T cells, type II diabetes
TMPA is a small molecule antagonist that disrupts the interaction between the nuclear receptor Nur77 (NR4A1) and the kinase LKB1 (STK11). This compound is a valuable research tool for investigating Nur77-LKB1 signaling in metabolic regulation, cancer, and inflammation, with utility in both cellular and animal models.
