VU 0365114 is a selective positive allosteric modulator of the muscarinic acetylcholine receptor M5 (CHRM5), potentiating acetylcholine-induced calcium mobilization with an EC50 of 2.7 µM. This small molecule is a valuable research tool for investigating M5 receptor function in neuropharmacology, utilized in both in vitro signaling assays and in vivo studies of central nervous system pathways.
