CDKN2A/P14arf Polyclonal Antibody, RBITC Conjugated, Rabbit
Artikelnummer:
BSS-BS-22495R-RBITC
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| Artikelname: | CDKN2A/P14arf Polyclonal Antibody, RBITC Conjugated, Rabbit |
| Artikelnummer: | BSS-BS-22495R-RBITC |
| Hersteller Artikelnummer: | bs-22495R-RBITC |
| Alternativnummer: | BSS-BS-22495R-RBITC-100 |
| Hersteller: | Bioss |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | IF, WB |
| Spezies Reaktivität: | Human |
| Konjugation: | RBITC |
| Alternative Synonym: | CDKN2A, p16INK4a, INK4, P16INK4, ARF, CCM2, CDK4 Inhibitor, CDK4 inhibitor p16 INK4, CDK4I, CDKN2, CDKN2A, Cell cycle negative regulator beta, CMM2, Cyclin dependent kinase 4 inhibitor A, Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4), Cyclin Dependent Kinase Inhibitor 2A, Cyclin dependent kinase inhibitor 2A isoform 4, Cyclin dependent kinase inhibitor 2A isoforms 1/2/3, Cyclin dependent kinase inhibitor p16, INK4A, MLM, MTS1, Multiple tumor suppressor 1, Multiple Tumor Supressor 1, p14, p14(ARF), p14ARF, p16, p16 INK4, p16INK4, p16INK4a, p19, p19(ARF), p19Arf, TP16. |
| Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its Lys63-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. |
| Application Verdünnung: | WB(1:300-5000), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200) |
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