Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 1 protein (396-500AA)
Konjugation:
Unconjugated
Alternative Synonym:
BBF-2 homolog,cAMP-responsive element-binding protein 3-like protein 1,cyclic AMP-responsive element-binding protein 3-like protein 1,OASIS,OI16,old astrocyte specifically-induced substance.
Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5-GTGXGCXGC-3 (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (PubMed:25310401).
