Recombinant Human Class E basic helix-loop-helix protein 40 protein (184-302AA)
Konjugation:
Unconjugated
Alternative Synonym:
basic helix-loop-helix domain containing, class B, 2,BHLHB2,class B basic helix-loop-helix protein 2,class E basic helix-loop-helix protein 40,Clast5,DEC1,differentially expressed in chondrocytes 1,differentially expressed in chondrocytes protein 1,differentiated embryo chondrocyte expressed gene 1,enhancer-of-split and hairy-related protein 2,HLHB2,SHARP2,SHARP-2,stimulated by retinoic acid gene 13 protein,STRA13,Stra14.
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5-CACGTG-3) found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.
