Recombinant Human N-lysine methyltransferase SMYD2 protein (115-272AA)
Konjugation:
Unconjugated
Alternative Synonym:
histone methyltransferase SMYD2,HSKM-B,KMT3C,lysine N-methyltransferase 3C,N-lysine methyltransferase SMYD2,SET and MYND domain-containing protein 2,zinc finger, MYND domain containing 14,ZMYND14.
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically methylates histone H3 Lys-4 (H3K4me) and dimethylates histone H3 Lys-36 (H3K36me2). Shows even higher methyltransferase activity on p53/TP53. Monomethylates Lys-370 of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at Lys-860.
