Recombinant Human TSC22 domain family protein 3 protein (58-134AA)
Konjugation:
Unconjugated
Alternative Synonym:
delta sleep-inducing peptide immunoreactor,DIP,DSIPI,DSIP-immunoreactive leucine zipper protein,DSIP-immunoreactive peptide,GILZ,glucocorticoid-induced leucine zipper protein,TSC22 domain family protein 3,TSC-22 related protein,TSC-22-like protein,TSC-22R,TSC-22-related protein.
Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity). Isoform 1 inhibits myogenic differentiation and mediates anti-myogenic effects of glucocorticoids by binding and regulating MYOD1 and HDAC1 transcriptional activity resulting in reduced expression of MYOG (By similarity).