Recombinant Human Pachytene checkpoint protein 2 homolog protein (181-390AA)
Konjugation:
Unconjugated
Alternative Synonym:
16E1BP,16E1-BP,HPV16 E1 protein binding protein,human papillomavirus type 16 E1 protein-binding protein,MVA3,OOMD9,pachytene checkpoint protein 2 homolog,SH3TC1/TRIP13 fusion,Thyroid hormone receptor interactor 13,thyroid receptor-interacting protein 13,TR-interacting protein 13,TRIP-13.
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed:28553959).