KCNMA1 Antibody
Artikelnummer:
ASB-OACA04701
- Bilder (3)
| Artikelname: | KCNMA1 Antibody |
| Artikelnummer: | ASB-OACA04701 |
| Hersteller Artikelnummer: | OACA04701 |
| Alternativnummer: | ASB-OACA04701-100UG,ASB-OACA04701-50UG |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | ELISA, IF, IHC |
| Spezies Reaktivität: | Human |
| Immunogen: | Recombinant Human Calcium-activated potassium channel subunit alpha-1 protein (1-86AA) |
| Konjugation: | Unconjugated |
| Alternative Synonym: | bA205K10.1,big potassium channel alpha subunit,BK channel,BK channel alpha subunit,BKCA alpha,BKCA alpha subunit,BKTM,CADEDS,Calcium-activated potassium channel subunit alpha-1,calcium-activated potassium channel, subfamily M subunit alpha-1,hSlo,IEG16,k(VCA)alpha,KCa1.1,LIWAS,Maxi K channel,MaxiK,maxi-K channel HSLO,mSLO1,PNKD3,potassium channel, calcium activated large conductance subfamily M alpha, member 1,potassium large conductance calcium-activated channel, subfamily M, alpha member 1,SAKCA,SLO,slo homolog,SLO1,SLO-ALPHA,slowpoke homolog,stretch-activated Kca channel. |
| Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX). |
| Klonalität: | Polyclonal |
| NCBI: | 3778 |
| Reinheit: | >95% |
| Formulierung: | Liquid |
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Immunofluorescent analysis of Hela cells at dilution of 1:100 and Alexa Fluor 488-congugate |
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Immunohistochemistry of paraffin-embedded human brain tissue at dilution 1:100 |
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Immunohistochemistry of paraffin-embedded human pancreatic tissue at dilution 1:100 |
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