The immunogen is a synthetic peptide directed towards the N-terminal region of Human TCF3
Alternative Synonym:
E2A, E47, p75, AGM8, ITF1, VDIR, TCF-3, bHLHb21
TCF3 is a transcriptional regulator. It is involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5-CANNTG-3. TCF3 binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. It binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.