RRP8 Antibody - N-terminal region
Artikelnummer:
ASB-ARP68566_P050
- Bilder (3)
| Artikelname: | RRP8 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP68566_P050 |
| Hersteller Artikelnummer: | ARP68566_P050 |
| Alternativnummer: | ASB-ARP68566_P050-25UL,ASB-ARP68566_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Equine, Human, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N-terminal region of Human RRP8 |
| Alternative Synonym: | NML, KIAA0409 |
| RRP8 is an essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD+/NADP+ ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. |
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Rabbit Anti-RRP8 Antibody Catalog Number: ARP68566 Formalin Fixed Paraffin Embedded Tissue: Human Adult Skeletal muscle Observed Staining: Cytoplasm in hepatocytes Primary Antibody Concentration: 1:600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 a€'' 2.0 sec |
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Host: Rabbit Target Name: RRP8 Sample Type: Fetal Kidney lysates Antibody Dilution: 1.0ug/ml |
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RRP8 Antibody - N-terminal region (ARP68566_P050) in Human Fetal Kidney using Western Blot |
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