Dnmt1 Antibody - N-terminal region
Artikelnummer:
ASB-ARP37033_P050
- Bilder (4)
| Artikelname: | Dnmt1 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP37033_P050 |
| Hersteller Artikelnummer: | ARP37033_P050 |
| Alternativnummer: | ASB-ARP37033_P050-25UL,ASB-ARP37033_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Mouse |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of mouse Dnmt1 |
| Alternative Synonym: | MTa, Dnmt, MCMT, Met1, Cxxc9, MTase, Met-1, Dnmt1o, MommeD, m.MmuI, MommeD2 |
| Dnmt1 methylates CpG residues.Dnmt1 preferentially methylates hemimethylated DNA. Dnmt1 associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance.Dnmt1 associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones.Dnmt1 mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, Dnmt1 is involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. |
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WB Suggested Anti-Dnmt1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Mouse Lung |
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Researcher:Austin J. Cooney, Baylor College of MedicineApplication:Western blottingSpecies+tissue/cell type: Lane 1: 15ug WT mouse ES lysate Lane 2: 15ug DNMT1 KO mouse ES lysatePrimary antibody dilution:1:1000Secondary antibody:Goat anti-rabbit-HRPSecondary antibody dilution:1:2500 |
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Researcher: Anonymous Application: Western Blotting Species+tissue/cell type: Lane 1: 20ug mouse mesenchymal stem cell lysate Primary antibody dilution: 1:2000 Secondary antibody: Anti-rabbit-HRP Secondary antibody dilution: 1:10,000 |
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Dnmt1 antibody - N-terminal region (ARP37033_P050) in Mouse Lung using Western Blot |
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