CHRNA7 Antibody - C-terminal region
Artikelnummer:
ASB-ARP36595_P050
- Bilder (4)
| Artikelname: | CHRNA7 Antibody - C-terminal region |
| Artikelnummer: | ASB-ARP36595_P050 |
| Hersteller Artikelnummer: | ARP36595_P050 |
| Alternativnummer: | ASB-ARP36595_P050-25UL,ASB-ARP36595_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Guinea pig, Human, Mouse, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the C-terminal region of human CHRNA7 |
| Alternative Synonym: | NACHRA7, CHRNA7-2 |
| The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. |
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Host: Rabbit Target Name: CHRNA7 Sample Type: Liver Tumor lysates Antibody Dilution: 1.0ug/ml |
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WB Suggested Anti-CHRNA7 antibody Titration: 1 ug/mL Sample Type: Human heart |
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WB Suggested Anti-CHRNA7 antibody Titration: 1 ug/mL Sample Type: Human liver |
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CHRNA7 Antibody - C-terminal region (ARP36595_P050) in Human Liver Tumor using Western Blot |
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