TP73 Antibody - N-terminal region
Artikelnummer:
ASB-ARP33457_P050
- Bilder (4)
| Artikelname: | TP73 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP33457_P050 |
| Hersteller Artikelnummer: | ARP33457_P050 |
| Alternativnummer: | ASB-ARP33457_P050-25UL,ASB-ARP33457_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Guinea pig, Human, Mouse, Porcine, Rat, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human TP73 |
| Alternative Synonym: | P73 |
| TP73 belongs to the p53 family. It participates in the apoptotic response to DNA damage. When overproduced, it activates transcription from p53-responsive promoters and induces apoptosis. TP53 may be a tumor suppressor protein. This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each others promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms, however, the biological validity and the full-length nature of most variants have not been determined. |
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WB Suggested Anti-TP73 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 293T cell lysate |
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WB Suggested Anti-TP73 Antibody Positive Control: Lane1: 10ug untransfected H1299, Lane2: 10ug GFP-TAp73 transfected H1299, Lane3: 10ug GFP-DNp73 transfected H1299, Lane4: 10ug GFP-DBDp73 transfected H1299 Primary Antibody Dilution : 1:1000 Secondary Antibody : Anti-rabbit-HRP Secondry Antibody Dilution : 1:5000 Submitted by: Francesca Grespi, VIB-Department for Molecular Biomedical Research, University of Gent |
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Host: Rabbit Target Name: TP73 Sample Type: Human Fetal Muscle Antibody Dilution: 1.0ug/ml |
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TP73 antibody - N-terminal region (ARP33457_P050) in Human 293T using Western Blot |
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