Bovine, Canine, Equine, Guinea pig, Human, Rabbit, Rat
Alternative Synonym:
RFT, PCM1, CXXC3
The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions, several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides, transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
WB Suggested Anti-MBD1 Antibody Titration: 1.0 ug/ml Positive Control: 293T Whole CellMBD1 is strongly supported by BioGPS gene expression data to be expressed in Human HEK293T cells
MBD1 antibody - C-terminal region (ARP32693_P050) in Human HEK293T using Western Blot
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