CCND1 Antibody - middle region
Artikelnummer:
ASB-ARP30163_P050
- Bilder (4)
| Artikelname: | CCND1 Antibody - middle region |
| Artikelnummer: | ASB-ARP30163_P050 |
| Hersteller Artikelnummer: | ARP30163_P050 |
| Alternativnummer: | ASB-ARP30163_P050-25UL,ASB-ARP30163_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Bovine, Canine, Equine, Human, Porcine, Rabbit, Rat, Yeast, Zebrafish |
| Immunogen: | The immunogen is a synthetic peptide directed towards the middle region of human CCND1 |
| Alternative Synonym: | BCL1, PRAD1, U21B31, D11S287E |
| CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. CCND1 has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
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Rabbit Anti-CCND1 Antibody Catalog Number: ARP30163_P050 Formalin Fixed Paraffin Embedded Tissue: Human Liver Tissue Observed Staining: Cytoplasm, Plasma membrane Primary Antibody Concentration: 1:600 Other Working Concentrations: N/A Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec |
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WB Suggested Anti-CCND1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: 721_B cell lysate |
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Lane 1: 30ug PKO lysateLane 2: 30ug PKO + Doxor lysate Primary Antibody Dilution: 1:1000 Secondary Antibody: Goat anti rabbit-HRP Secondary Antibody Dilution: 1:5000 Gene Name: CCND1 Submitted by: Tobias Wagner, Institute for Biochemistry and Biophysics |
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CCND1 antibody - middle region (ARP30163_P050) in Human 721_B using Western Blot |
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