Frizzled 5 Antibody, Rabbit, Polyclonal
Artikelnummer:
ABT-AP51219
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| Artikelname: | Frizzled 5 Antibody, Rabbit, Polyclonal |
| Artikelnummer: | ABT-AP51219 |
| Hersteller Artikelnummer: | AP51219 |
| Alternativnummer: | ABT-AP51219-100UL |
| Hersteller: | Abcepta |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, IHC-P, WB |
| Spezies Reaktivität: | Human, Mouse, Rat |
| Alternative Synonym: | Frizzled-5, Fz-5, hFz5, FzE5, FZD5, C2orf31 |
| Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta- catenin pathway. |
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