EXO1 Antibody, Rabbit, Polyclonal
Artikelnummer:
ABT-AP51200
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| Artikelname: | EXO1 Antibody, Rabbit, Polyclonal |
| Artikelnummer: | ABT-AP51200 |
| Hersteller Artikelnummer: | AP51200 |
| Alternativnummer: | ABT-AP51200-100UL |
| Hersteller: | Abcepta |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | ELISA, ICC, WB |
| Spezies Reaktivität: | Human, Mouse |
| Alternative Synonym: | Exonuclease 1, hExo1, 31--, Exonuclease I, hExoI, EXO1, EXOI, HEX1 |
| 5->3 double-stranded DNA exonuclease which may also possess a cryptic 3->5 double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts directed by strand breaks located either 5 or 3 to the mismatch. Also exhibits endonuclease activity against 5-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. |
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