Biotinylated Cynomolgus Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His,Avitag(TM)&Tag Free (MALS verified), Human
Artikelnummer:
ABS-IT8-C82W3-200UG
Hersteller Artikelnummer:
IT8-C82W3-200ug
Alternativnummer:
ABS-IT8-C82W3-200UG
Hersteller:
AcroBiosystems
Wirt:
Human
Kategorie:
Proteine/Peptide
Spezies Reaktivität:
Monkey
Konjugation:
Biotin
Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGFbeta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1MMP, which releases active TGFbeta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGFbeta from latency through nonproteolytic mechanisms. Downstream effects of TGFbeta activation include control of cell growth and associated vascularization. - Proteine/Peptide
