Polyclonal Antibody to 14-3-3 sigma
Artikelnummer:
ABI-11-1020
- Bilder (3)
| Artikelname: | Polyclonal Antibody to 14-3-3 sigma |
| Artikelnummer: | ABI-11-1020 |
| Hersteller Artikelnummer: | 11-1020 |
| Alternativnummer: | ABI-11-1020-100UG |
| Hersteller: | Abeomics |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | IHC, WB |
| Spezies Reaktivität: | Human |
| Immunogen: | Full length recombinant 14-3-3 sigma protein was used as the immunogen for this antibody. |
| Alternative Synonym: | SFN||HME1 |
| 14-3-3 sigma is a member of a highly conserved family of 14-3-3 proteins that are present in all eukaryotic organisms. There are 7 known human 14-3-3 isotypes and they play important roles in many biological activities by binding to and altering the subcellular localization and/or stability of key molecules in various signaling cascades. 14-3-3 sigma was originally characterized as a human mammary epithelium marker 1 and later rediscovered as an important molecule for cell cycle checkpoint regulation. Recently it has been reported that 14-3-3 sigma may serve as a prognosis marker predicting survival of pancreatic cancer patient treatment. 14-3-3 Sigma is the only 14-3-3 isoform induced by the tumor suppressor protein p53, in response to Gamma-irradiation and other DNA-damaging agents. 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression and acts as a tumor suppressor gene that is inactivated by methylation of its 5 CpG islands in epithelial tumor cells. Two isoforms of the human proteins are produced by alternative splicing. |
| Application Verdünnung: | Western blot analysis: 1-3 µg/ml, Immunohistochemical analysis: 10 µg/ml |
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Fig-1: Western blot analysis of14-3-3 sigma.Anti-14-3-3 sigmaantibody (11-1020) was used at 1 µg/ml on Molt-4lysate. |
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Fig-2: Immunohistochemical analysis of 14-3-3 sigma. Anti-14-3-3 sigma antibody (11-1020) in human Colon tissue at 10 µg/ml. |
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Fig-3 : Immunohistochemical analysis of 14-3-3 sigma. Anti-14-3-3 sigma antibody (11-1020) in human Skin tissue at 10 µg/ml. |
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