Monoclonal antibody to MyD88 (Clone: ABM2H20)
Artikelnummer:
ABI-10-3012
- Bilder (3)
| Artikelname: | Monoclonal antibody to MyD88 (Clone: ABM2H20) |
| Artikelnummer: | ABI-10-3012 |
| Hersteller Artikelnummer: | 10-3012 |
| Alternativnummer: | ABI-10-3012-100UG |
| Hersteller: | Abeomics |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | FACS, WB |
| Spezies Reaktivität: | Human, Mouse |
| Immunogen: | A partial length recombinant protein of human MyD88 (amino acids 13-221) was used as an immunogen for this antibody. |
| Alternative Synonym: | Myeloid differentiation primary response protein MyD88 |
| MyD88 (Myeloid differentiation factor) is an essential adaptor molecule in all TLR (Toll-like receptor) signaling pathways except TLR3. MyD88 is composed of an N-terminal (Death Domain) and a highly conserved C-terminal TIR (Toll/interleukin-1 Receptor) domain. It is found to stimulate IL-1R/IL18R-mediated signaling. MyD88-dependent signaling is also important in the regulation of innate as well as acquired immunity, in particular, T-cell responses, to various microbial pathogens. After activation of TLRs, MyD88 is phosphorylated and subsequently recruits IRAKs (IL-1R Associated Kinases) and other downstream proteins such as TRAF6, finally resulting in activation of the NF-kappaB (nuclear factor kappa B) pathway. |
| Application Verdünnung: | Western blot analysis: 0.1-2 µg/ml, FACS Analysis: 0.5-1 µg/ml |
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Figure:3- Western blot analysis of MyD88. Anti-MyD88 antibody (Clone: ABM2H20) was tested at 1 µg/ml on (1) Raw and (2) EL-4 lysates. |
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Fig. 1: Intracellular flow analysis of MyD88 in Jurkat using 0.5 µg/10 6 cells of MyD88 antibody (Clone: ABM2H20). Green represents isotype control, red represents anti-MyD88 antibody. Goat anti-mouse PE conjugate was used as secondary antibody. |
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Fig. 2: Western blot analysis of MyD88. Anti-MyD88 antibody (Clone: ABM2H20) was tested at 0.1 µg/ml on h Kidney lysate. |
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