Integrin beta 3(N-terminus) Antibody, Mouse, Monoclonal
Catalog Number:
ABT-AP52700
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| Article Name: | Integrin beta 3(N-terminus) Antibody, Mouse, Monoclonal |
| Biozol Catalog Number: | ABT-AP52700 |
| Supplier Catalog Number: | AP52700 |
| Alternative Catalog Number: | ABT-AP52700-100UL |
| Manufacturer: | Abcepta |
| Host: | Mouse |
| Category: | Antikörper |
| Application: | WB |
| Species Reactivity: | Human |
| Alternative Names: | BDPLT2,CD 61,CD61,CD61 antigen,GP3A,GPIIIa,GT,HPA 1,HPA 4,Integrin beta 3 (platelet glycoprotein IIIa antigen CD61),Integrin beta chain beta 3,Integrin beta-3,ITB3_HUMAN, ITG B3,ITGB 3,ITGB3,NAIT,Platelet fibrinogen receptor beta subunit,Platelet glycoprotein IIIa,platelet glycoprotein IIIa precursor,Platelet membrane glycoprotein IIIa,PTP. |
| Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposis sarcoma lesions. |
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