hnRNP K (pS284) Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AP51649
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| Article Name: | hnRNP K (pS284) Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AP51649 |
| Supplier Catalog Number: | AP51649 |
| Alternative Catalog Number: | ABT-AP51649-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, ICC, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Alternative Names: | Heterogeneous nuclear ribonucleoprotein K, hnRNP K, Transformation up-regulated nuclear protein, TUNP, HNRNPK, HNRPK |
| One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. |
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