UBE2A/B Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AP51597
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| Article Name: | UBE2A/B Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AP51597 |
| Supplier Catalog Number: | AP51597 |
| Alternative Catalog Number: | ABT-AP51597-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | WB |
| Species Reactivity: | Human, Mouse, Rat |
| Alternative Names: | Ubiquitin-conjugating enzyme E2 A, RAD6 homolog A, HR6A, hHR6A, Ubiquitin carrier protein A, Ubiquitin-protein ligase A, UBE2A, RAD6A |
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at Lys-120 to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes Lys-11, as well as Lys-48-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. |
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