TSC2 (pT1462) Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AP51590
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| Article Name: | TSC2 (pT1462) Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AP51590 |
| Supplier Catalog Number: | AP51590 |
| Alternative Catalog Number: | ABT-AP51590-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, ICC, IHC-P, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Alternative Names: | Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4 |
| In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase- activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors. |
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