Topoisomerase 3 beta1 Antibody, Rabbit, Polyclonal
Catalog Number:
ABT-AP51579
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| Article Name: | Topoisomerase 3 beta1 Antibody, Rabbit, Polyclonal |
| Biozol Catalog Number: | ABT-AP51579 |
| Supplier Catalog Number: | AP51579 |
| Alternative Catalog Number: | ABT-AP51579-100UL |
| Manufacturer: | Abcepta |
| Host: | Rabbit |
| Category: | Antikörper |
| Application: | ELISA, IHC-P, IP, WB |
| Species Reactivity: | Human, Mouse, Rat |
| Alternative Names: | DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B, TOP3B1 |
| Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity. |
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