SMN1 Antibody - N-terminal region
Artikelnummer:
ASB-ARP40209_P050
- Bilder (6)
| Artikelname: | SMN1 Antibody - N-terminal region |
| Artikelnummer: | ASB-ARP40209_P050 |
| Hersteller Artikelnummer: | ARP40209_P050 |
| Alternativnummer: | ASB-ARP40209_P050-25UL,ASB-ARP40209_P050-100UL |
| Hersteller: | Aviva |
| Wirt: | Rabbit |
| Kategorie: | Proteine/Peptide |
| Applikation: | WB |
| Spezies Reaktivität: | Canine, Equine, Guinea pig, Human, Mouse, Porcine, Rabbit, Rat |
| Immunogen: | The immunogen is a synthetic peptide directed towards the N terminal region of human SMN1 |
| Alternative Synonym: | SMA, SMN, SMA1, SMA2, SMA3, SMA4, SMA , SMNT, BCD541, GEMIN1, TDRD16A, T-BCD541 |
| SMN1 localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein.This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy, mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7 which is thought to be an exon splice enhancer. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Two transcript variants are produced by this gene. |
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WB Suggested Anti-SMN1 Antibody Titration: 0.2-1 ug/ml Positive Control: HepG2 |
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Host: Rabbit Target Name: NOP56 Sample Type: MCF7 Antibody Dilution: 1.0ug/mlSMN1 is supported by BioGPS gene expression data to be expressed in MCF7 |
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Host: Rabbit Target Name: NOP56 Sample Type: Human Fetal Muscle Antibody Dilution: 1.0ug/ml |
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Host: Rabbit Target Name: NOP56 Sample Type: Human Fetal Brain Antibody Dilution: 1.0ug/ml |
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Host: Mouse Target Name: SMN1 Sample Tissue: Mouse Kidney Antibody Dilution: 1ug/ml |
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SMN1 antibody - N-terminal region (ARP40209_P050) in Human HepG2 using Western Blot |
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