SMARCC1 Antibody, Mouse, Monoclonal
Artikelnummer:
ABT-AP52766
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| Artikelname: | SMARCC1 Antibody, Mouse, Monoclonal |
| Artikelnummer: | ABT-AP52766 |
| Hersteller Artikelnummer: | AP52766 |
| Alternativnummer: | ABT-AP52766-100UL |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | AI115498,BAF 155,BAF155,BRG 1 associated factor 155,BRG1 associated factor 155,BRG1-associated factor 155,Chromatin remodeling complex BAF155 subunit,CRACC 1,CRACC1, Mammalian chromatin remodeling complex BRG 1 associated factor 155,Mammalian chromatin remodeling complex BRG1 associated factor 155,Rsc 8,Rsc8,SMARC C1,SMARCC 1,SMARCC1, SMRC1_HUMAN,SRG 3,SRG3,SWI 3,SWI/SNF complex 155 kDa subunit,SWI/SNF related matrix associated actin dependent regulator of chromatin c1,SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1,SWI3. |
| Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). |
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