PRMT1 Antibody, Mouse, Monoclonal
Artikelnummer:
ABT-AP52749
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| Artikelname: | PRMT1 Antibody, Mouse, Monoclonal |
| Artikelnummer: | ABT-AP52749 |
| Hersteller Artikelnummer: | AP52749 |
| Alternativnummer: | ABT-AP52749-100UL |
| Hersteller: | Abcepta |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | ANM 1,ANM1,ANM1_HUMAN,complete cds,HCP 1,HCP1,Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2,Heterogeneous nuclear ribonucleoproteins methyltransferase like 2,Heterogeneous nuclear ribonucleoproteins methyltransferase like2,Histone-arginine N-methyltransferase PRMT1,HMT 2,HMT1 (hnRNP methyltransferase,HMT1 (hnRNP methyltransferase S. cerevisiae) like 2,HMT1 hnRNP methyltransferase,HMT1 hnRNP methyltransferase like 2 (S. cerevisiae),HMT1 hnRNP methyltransferase like 2,HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae),HMT2,HRMT1 L2,HRMT1L 2,HRMT1L2,Human mRNA for suppressor for yeast mutant,Human mRNA for suppressor for yeast mutant complete cds,Interferon receptor 1 bound protein 4,Interferon receptor 1 bound protein4,Interferon receptor 1-bound protein 4,Interferon receptor 1bound protein 4,IR1 B4,IR1B 4,IR1B4,Mrmt 1,Mrmt1,PRMT 1,PRMT1,Protein arginine methyltransferase 1,Protein arginine N methyltransferase 1,Protein arginine N methyltransferase1,Protein arginine N-methyltransferase 1,R1B4,S. cerevisiae like 2. |
| Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 Arg-4 (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. |
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