HUR Antibody, Rabbit, Polyclonal
Artikelnummer:
ABT-AP52000
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| Artikelname: | HUR Antibody, Rabbit, Polyclonal |
| Artikelnummer: | ABT-AP52000 |
| Hersteller Artikelnummer: | AP52000 |
| Alternativnummer: | ABT-AP52000-100UL |
| Hersteller: | Abcepta |
| Wirt: | Rabbit |
| Kategorie: | Antikörper |
| Applikation: | WB |
| Spezies Reaktivität: | Human |
| Alternative Synonym: | ELAV-like protein 1, Hu-antigen R, HuR, ELAVL1, HUR |
| Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5- UUUU[AG]UUU-3 motif in vitro. With ZNF385A, binds the 3-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. |
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